alternative rna splicing การใช้

• Due to alternative RNA splicing, several ER isoforms are known to exist.
• The long form ( alternative RNA splicing.
• This large amount of diversity is accomplished by having multiple cadherin encoding genes combined with alternative RNA splicing mechanisms.
• Each of the members ( GRIA1-4 ) include flip and flop isoforms generated by alternative RNA splicing.
• The control of alternative RNA splicing is performed by a complex network of signaling molecules that respond to a wide range of intracellular and extracellular signals.
• Alternative RNA splicing of 8 of them significantly increases structural variations of fsTnT . Two variable regions of the fsTnT protein are generated by alternative splicing ( Fig . 3 ).
• Silencing the m 6 A methyltransferase significantly affects gene expression and alternative RNA splicing patterns, resulting in modulation of the p53 ( also known as TP53 ) signalling pathway and apoptosis.
• The alteration can occur in the form of nonsense mutations or mutations which alter the splice sites, and result in alternative RNA splicing, leading to synthesis of a different or modified protein.
• Additionally, silencing the m 6 A methyltransferase significantly affects gene expression and alternative RNA splicing patterns, resulting in modulation of the p53 ( also known as TP53 ) signalling pathway and apoptosis.
• The length of the telomere strand has senescent effects; telomere shortening activates extensive alterations in alternative RNA splicing that produce senescent toxins such as progerin, which degrades the tissue and makes it more prone to failure.
• Additionally, Hood was among the first to study, at the gene level, the MHC ( major histocompatibility complex ) gene family and the T-cell receptor gene families as well as the being among first to demonstrate that alternative RNA splicing was a fundamental mechanism for generating alternative forms of antibodies.